A Porous poly(1,8 octanediol-co-citrate) Biodegradable Elastomer for Drug Delivery

Porous poly(1,8 octanediol-co-citrate) (POC) polymer networks were formed using polyethylene glycol dimethyl ether (PEGDM) as the polymer porogen. POC membranes can be made with a high degree of porosity and interconnectivity. POC membrane material can be used for drug delivery applications via pore collapse caused by a freeze-drying process. Different blending ratios of PEGDM can alter mechanical and biodegradation properties of the elastomer. The reagents used in the processing are non-toxic and show good biocompatibility in vivo.

Example of POC scaffolds in non porous and porous tubular constructs and flat sheets for cardiovascular tissue engineering applications.

 

R. Hoshi and G. Ameer

Read other Highlights.

 

The Materials Research Science and Engineering Center (MRSEC) is supported by the National Science Foundation under NSF Award Number DMR-0520513. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect those of the National Science Foundation.
© 2008 Northwestern University